10 Night Cruise sailing from Pittsburgh to St Louis aboard Queen of the Mississippi.

Experience two of America’s greatest rivers on this 11-day adventure through the heartland. Enjoy the idyllic countryside of the Ohio River and the wonder of the mighty Mississippi that inspired Mark Twain. The Ohio River was pivotal in the development and exploration of the American West and along the way we highlight much that has defined our American roots from the Civil War to bluegrass music. Or, you can take a milder pace and just kick back with a rocking chair and a glass of sweet tea on the sun deck while American Cruise Lines handles the rest.

Each port of call showcases a new element of Americana. In Henderson, for instance, you may visit the John James Audubon Museum, which features many original works and join our expert guide to learn about the sense of natural wonder that Audubon instilled in so many Americans. While in Louisville, we are treated to a behind the scenes tour of the Churchill Downs, the site of the famed Kentucky Derby, and sample the finest bourbon at the famous Jim Beam Distillery, each destination with a distinct American story to tell.

NOTE: Cruise operates in approximate reverse order to the itinerary outlined below.

Day 1 St Louis, MO
Departure Day.

Day 2 St. Louis, MO
St. Louis is sure to win you over. Take in the Gateway Arch Riverfront, highlighted by the majestic Gateway Arch, the largest man-made monument in the U.S. Enjoy St. Louis’ many world-class attractions, including the Art Museum, Science Center, Anheuser-Busch Brewery, and the Missouri History Museum. End your day by relaxing at the Missouri Botanical Garden, one of the world’s most popular public gardens.

Day 3 Cape Girardeau, MO
Enjoy the charming features of this historic town that was once a French trading post and lively river port in the late 1800s. Today it boasts Civil War sites and a tranquil setting commemorating the Cherokee Trail of Tears. Marvel at the outdoor murals reflecting the area's rich heritage and enjoy shore excursions to Cape River Heritage Museum and the Red House Interpretive Center.

Day 4 Paducah, KY
Residing at the confluence of the Tennessee River and the Ohio River, Paducah will have you feeling as if you stepped back in time as you walk the streets of this Chicasaw village site. Discover Paducah’s rich history by exploring the Wall to Wall Mural Program, a collection of over 50 murals that covers a number of subjects including Native American history, the Civil War and area landmarks such as the Old Carnegie Library.

Day 5 Henderson, KY
You won’t miss the presence of notable resident, John James Audubon, who's “Birds of America” paintings are recreated in bronze statues throughout Henderson. Named after President Washington’s home on the Potomac, this bucolic river town is steeped in fascinating lore. Let our expert guide lead you on a tour of our famous first President's historic home and grounds.

Day 6 and 7 Louisville, KY
Named after King Louis XVI of France, Louisville is best known for the famed Kentucky Derby, the first leg of the Triple Crown of Thoroughbred Racing. When you visit, you’ll also discover why Louisville is often referred to as either the northernmost Southern city or the southernmost Northern city in the United States.

Day 8 Cincinnati, OH
As you disembark in Cincinnati, take some time to visit the numerous National Historic Sites via walking tours through Cincinnati’s oldest neighborhoods abounding in eclectic architecture. Visit the William Howard Taft National Historic Museum, the National Underground Railroad Freedom Center and Betts House.

Day 9 Maysville, KY
Maysville, KY is a quaint town on the Ohio River with a rich history. An important stop on the Underground Railroad, Maysville was host to Harriet Beecher Stowe in 1883. Your stop will include idyllic country scenery and the native sounds of original bluegrass country music.

Day 10 Marietta, OH
The second-largest city in the Parkersburg-Marietta-Vienna West Virginia-Ohio metropolitan area, Marietta was named in honor of Marie Antoinette. The town saw booming times during the 18th and 19th centuries, the city's economy was booming as its location on the Ohio River made it an attractive stop for commercial steamboats and travelers.

Day 11 Pittsburgh, PA
End your journey in the "steel city," Pittsburgh, PA. Long known for steel manufacturing, Pittsburgh was an essential stop along the Ohio River for national and international commerce making it a wealthy town in the 18th and 19th centuries.